5. Symphytum officinale has been shown to act as a cell proliferant and have analgesic effects in clinical studies.
Roum Arch Microbiol Immunol 1993
Action of some proteic and carbohydrate components of Symphytum officinale upon normal and neoplastic cells.
Crude water extracts of symphytum officinale stimulated in vivo proliferation of studied neoplastic cells. Therefore, Symphytum is an effective cell proliferant.
Traditional usage of comfrey as a cell proliferant is substantiate with this clinical trial.
F.M. van den Dungen et al. Planta Med 57(2) 1991
Inhibition of Compliment Activity by High Molecular Compounds of Symphytum officinale.
Common comfrey, of Symphytum officinale L. is well known for its wound healing properties. At the site of a dermal wound, activation of complement is one of a complex series of processes. Since complement factors upon activation exert important immuno-regulatory effects, modulation of complement activity may promote the healing of wounds.
Traditional usage of comfrey as a cell proliferant is substantiate with this clinical trial
R.S. Goldman et al. Fitoterapia LVI(6) 323
Wound Healing and Analgesic Effects of Crude Extracts of Symphytum officinale in Rats.
The crude extract of S. officinale (comfrey) afforded the cicatrization process by increasing at first the number of fibroblasts and in a later phase, the number of collagen fibers in experimental lesions produced in rats. The number of blood vessels was also increased on the seventh day of treatment. On experimental edema induced by carrageenin in rat's paws, the crude extract at doses of 150 and 300 mg/kg showed no effect. Analgesic effect was seen with doses of 300 mg/kg.
Comfrey's use as a burn remedy is substantiate in this clinical trial.